目的 研究淫羊藿经羊脂油炮制后对黄酮类成分生物利用度的影响。方法 采用药理效应法与血药浓度法分别测定淫羊藿总黄酮与淫羊藿苷、宝藿苷Ⅰ的生物利用度。结果 淫羊藿黄酮在羊脂油的作用下自组装形成胶束后,淫羊藿总黄酮、淫羊藿苷和宝藿苷Ⅰ与原形药物相比,ρmax分别提高了77.94%、38.99%和49.90%,AUC0-t分别提高了95.19%、37.76%和43.49%,AUC0-∞分别提高了119.35%、35.37%和46.26%。各药动学参数显示在炮制辅料羊脂油的作用下,淫羊藿活性黄酮自组装形成胶束后,生物利用度显著提高。 结论 炮制辅料羊脂油提高了淫羊藿黄酮生物利用度,促进了其在体内的吸收。
Abstract
OBJECTIVE To study the influence of bioavailability of Epimedium flavonoids after processing by suet oil. METHODS Pharmacokinetics parameters of rats Epimedium flavonoids and icariin and baohuoside Ⅰ was determining by the method of pharmacology effect and plasma concentration method. RESULTS The concentration of the Epimedium flavonoids, icariin and baohuoside Ⅰ in micelles groups were higher than that of the active pharmaceutical ingredient(API). ρmax were increased by 77.94%, 38.99% and 49.90%; AUC0-t increased by 95.19%, 37.76% and 43.49%; AUC0-∞ increased by 119.35%, 35.37% and 46.26% on Epimedium flavonoids, icariin and baohuoside Ⅰ group. CONCLUSION Suet oil improved the bioavailability of Epimedium flavonoids and promoted its absorption.
关键词
淫羊藿黄酮 /
生物利用度 /
羊脂油炙 /
自组装胶束
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Key words
Epimedium flavonoid /
bioavailability /
suet oil /
self-assembled micelle
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中图分类号：
R284
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参考文献
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脚注
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基金
国家自然科学基金资助项目(81274088, 81503253)
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